Lion's Mane Triple Extract

One of the most valued culinary and medicinal mushrooms in Traditional Asian medicine (TAM).  It’s also known as ‘Yamabushitake’ or ‘mountain priest fungus’ – named after the Yamabushi Buddhist monks who, like this mysterious mushroom, prefer a solitary life. Lion’s mane has long been used in Ancient Chinese and Japanese culture as a nutraceutical that helps to maintain the five main internal organs: the heart, liver, lungs, spleen and kidneys. Reported from and native to North America, Europe, Asia. On dying or dead oak, walnut, beech, maple, sycamore, and other broad-leaf trees. It is saprotrophic and grows primarily on hardwood. (Stamets & Wu, 2002)

Potential actions:

• Prebiotic - (Diling et al., 2017)
• Anti-inflammatory - (Diling et al., 2017)
• Anti-microbial – against Helicobacter pylori - (Diling et al., 2017)
• Antioxidant - (Stamets & Wu, 2002)
• Anti-tumour - (Diling et al., 2017)
• Immunomodulatory/immune stimulation – dose dependent -(Mirre & Portela, 2016)
• Neurotrophic & Neuroprotective (Mori, et al., 2008) - Promotes NGF (Nerve Growth Factor) synthesis (supports neurone growth) - (Li et al., 2018)
• Reduction in Anxiety & Depression (Fijałkowska, et al., 2022)

Known compounds:

• Galactoxyloglucan, Mannoglucoxylan, Xylan, & glucoxylans - β-glucans & β-glucoxylans
• Hericenones, & other Terpenoids found in fruiting bodies.(Erinacines found only in mycelium). They activate brain cells to produce nerve growth factor (NGF) that promotes & develops production of new neurone growth. As well as helps protect & maintain nervous system.
• 5-Hydroxy-L-tryptophan (5-HTP) - immediate precursor of serotonin (neurotransmitter) targeted in pharmacotherapy for major depressive disorder.
• Adenosine - Nucleoside (building blocks of DNA/RNA) - Adenosine - involved in energy transfer within cells (ATP & ADP) as well as promoting sleep.
• Phenolic compounds
• Sterols & ergosterol – provitamin D2
• Minerals – Potassium, Phosphorus, Calcium, Magnesium, Iron & Zinc.
• Vitamins - B1, B2, B3, B5, B9, C, D2
• Amino Acids - mainly Glutamic acid, Aspartic acid, & Alanine

(Li et al., 2018), (Mirre & Portela, 2016), (Stamets & Wu, 2002), (Diling et al., 2017), (Diling et al., 2017), (Wang, K et al., 2015), (Fijałkowska, et al., 2022)

Recommended Dosage:

1-2ml daily, either diluted in tea, coffee, water, food or taken directly from dropper to mouth. Do not exceed this.

NB. extract may lose some efficacy/bioavailability with the addition of hot temperatures (adding to hot drinks) as the final product contains a cold water portion in its ratio. So ideally taking dropper to mouth.

Research has shown Lion's Mane to benefit the following:

Regeneration of epithelium for recovery of GI: leaky gut syndrome, gastric & duodenal ulcers, gastritis, IBS/IBD, Crohn’s disease, and similar. Nerve growth stimulation & protector of myelin sheath: Parkinson’s disease, Alzheimer’s, Multiple Sclerosis, Dementia, epilepsy, cognitive impairment alike. Also, may help with neurodiverse conditions. Certain Cancers (Gastric, Colon, Breast, Liver, Leukaemia), Anaemia, Stress, Insomnia, Anxiety, Depression, reducing inflammation. For everyday focus & concentration.

(Li et al., 2018), (Mirre & Portela, 2016), (Stamets & Wu, 2002), (Diling et al., 2017), (Diling et al., 2017), (Wang, K et al., 2015), (Fijałkowska, et al., 2022).

Atlantic Fungi Co-op and it’s members make no claims as to the medicinal uses of their products for specific medical conditions. These are sold as food supplements.

All suggestions on this page are our interpretation of the current scientific literature. Where research has shown positive action, it is often achieved in clinical settings. Please do your own due diligence in researching information and consulting the appropriate medical professional.

• Li, I.-C. et al. (2018) ‘Neurohealth properties of hericium erinaceus mycelia enriched with erinacines’, Behavioural Neurology, 2018, pp. 1–10. doi:10.1155/2018/5802634.
• Diling, C. et al. (2017) ‘Immunomodulatory activities of a fungal protein extracted from hericium erinaceus through regulating the gut microbiota’, Frontiers in Immunology, 8. doi:10.3389/fimmu.2017.00666.
• Diling, C., Xin, Y., et al. (2017) ‘Extracts from hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota’, Oncotarget, 8(49), pp. 85838–85857. doi:10.18632/oncotarget.20689.
• Stamets, P. and Wu, Y.C.D. (2002) MycoMedicinals: An informational treatise on mushrooms. Olympia: MycoMedia.
• Mirre, J.C. and Portela, C.F. de A. (2016) 12 medicinal mushrooms. Bora, Pontevedra: Hifas da Terra.
• Rahman, M. A., Abdullah, N., & Aminudin, N. (2014). 'Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom)'. BioMed research international,2014,828149. accessed 16 May 2024. https://pubmed.ncbi.nlm.nih.gov/24959591/
• Lee, K. F., et al. (2014). 'Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine'. International journal of molecular sciences,15(9), 15073–15089. Accessed 16 May 2024. https://pubmed.ncbi.nlm.nih.gov/25167134/
• Wang, K., et al. (2015). 'Erinacerins C-L, isoindolin-1-ones with α-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus'. Journal of natural products,78(1), 146–154. https://pubmed.ncbi.nlm.nih.gov/25565282/.
• Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). 'Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial'. Phytotherapy research : PTR, 23(3), 367–372. https://pubmed.ncbi.nlm.nih.gov/18844328/
• Mori, K., et al. (2008). 'Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells'. Biological & pharmaceutical bulletin, 31(9), 1727–1732. https://pubmed.ncbi.nlm.nih.gov/18758067/
• Wong, K. H., Sabaratnam, V., Abdullah, N., Kuppusamy, U. R.,
  & Naidu, M. (2011). 'Neuroregenerative potential of lion’s mane mushroom,
  Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in the treatment
  of peripheral nerve injury (Review)'. International Journal of
  Medicinal Mushrooms, 13(5), 501-506.
  https://www.dl.begellhouse.com/journals/708ae68d64b17c52,03ea8c440cfbb276,23c2fd3840f4e0c9.html
• Ma,L., Chen, H., Zhang, L., & Zhang, Y. (2010). 'Cytotoxic isoindolinone derivatives from the mushroom Hericium erinaceus.' Journal of Natural Products, 73(6), 976-979.
• Xie, G., Tang, L., Xie, Y., & Xie, L. (2022). Secondary Metabolites from Hericium erinaceus and their Anti-Inflammatory Activities.' Molecules (Basel, Switzerland),27(7), 2157. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000484/
• Fijałkowska, A., Jędrejko, K., Sułkowska-Ziaja, K., Ziaja, M., Kała, K., & Muszyńska, B. (2022). 'Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.' Foods (Basel, Switzerland),11(10), 1489. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9141008/.
• Zhang, J., Chen, H., Chen, M., Ren, F., & Xue, C.
  (2012). 'Comparison of physicochemical properties of polysaccharides from the
  fruiting bodies and mycelia of Hericium erinaceus.' Carbohydrate
  Polymers, 88(2), 347-350.
• Yang, et al., (2021). 'Rapid Identification of Chemical Constituents in Hericium erinaceus Based on LC-MS/MS Metabolomics'. Journal of food Quality. 2021, 5560626. [Google Scholar]